Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development

Table 5

RETN haplotype frequencies in healthy controls and OSCC patients.

Haplotype block				Controls	Patients
rs3745367 G/A	rs7408174 T/C	rs1862513 G/C	rs3219175 G/A	n = 2400	n = 1870	OR (95% CI)	AOR (95% CI)
G	T	G	G	679 (28.3%)	492 (26.3%)	1.000 (reference)	1.000 (reference)
G	C	G	G	475 (19.8%)	422 (22.6%)	1.226 (1.029-1.461)	1.212 (0.965-1.522)
A	T	C	A	318 (13.2%)	291 (15.6%)	1.263 (1.037-1.538)	1.150 (0.890-1.486)
A	T	G	G	257 (10.7%)	226 (12.1%)	1.214 (0.981-1.502)	1.376 (1.039-1.823)
A	T	C	G	189 (7.9%)	153 (8.2%)	1.117 (0.876-1.424)	1.219 (0.890-1.672)
G	T	C	G	191 (8.0%)	146 (7.8%)	1.055 (0.826-1.347)	1.062 (0.773-1.460)
G	T	C	A	67 (2.8%)	57 (3.0%)	1.174 (0.810-1.703)	1.051 (0.644-1.716)
A	C	C	A	86 (3.6%)	36 (1.9%)	0.578 (0.385-0.867)	0.712 (0.427-1.188)
G	C	C	G	63 (2.6%)	30 (1.6%)	0.657 (0.419-1.031)	0.889 (0.509-1.552)
A	C	G	G	46 (1.9%)	14 (0.7%)	0.420 (0.228-0.773)	0.343 (0.161-0.728)
A	C	C	G	19 (0.8%)	1 (0.1%)	0.073 (0.010-0.544)	0.176 (0.019-1.643)
G	C	C	A	6 (0.2%)	0 (0.0%)	-	-
A	T	G	A	2 (0.1%)	2 (0.1%)	1.380 (0.194-9.831)	1.620 (0.105-24.958)
G	C	G	A	2 (0.1%)	0 (0.0%)	-	-

Multivariate analysis adjusted for the effects of betel quid chewing, tobacco smoking, and alcohol consumption.
p=0.0225; p=0.0201; p=0.0081; p=0.0053; p=0.0107; p=0.0258; p=0.0054.
OSCC: oral squamous cell carcinoma; OR: odds ratio; AOR: adjusted odds ratio.