The Thomsen-Friedenreich Antigen-Specific Antibody Signatures in Patients with Breast Cancer
Table 2
Receiver operating characteristic (ROC) curves analysis for distinguishing cancer patients from controls.
Parameter
stage
Sensitivity
Specificity
ROC Curve Area
P Value
ACC
Sensitivity at 90%
(95% Cl)
(95% Cl)
(95% Cl)
Specificity
IgG/IgM ratio
all
60.3% (47.2% - 72.4%)
60.8% (53.6% - 67.7%)
0.636 (55.9% - 71.4%)
0.0012
0.603
26.8%
IgG/IgM ratio
0-3a
60.3% (47.2% - 72.4%)
64.7% (56.5% - 72.3%)
0.651 (57.2% - 73.1%)
0.0005
0.620
28.7%
IgG/IgA ratio
all
60.7% (46.8% - 73.5%)
58.8% (51.5% - 65.8%)
0.636 (54.8% - 72.3%)
0.0020
0.592
17.0%
IgG/IgA ratio
0-1
66.1% (52.2% - 72.2%)
65.6% (52.7% - 77.1%)
0.690 (59.4% - 78.7%)
0.0003
0.658
21.9%
SNA binding
all
63.6% (49.5% - 76.2%)
60.5% (53.3% - 67.4%)
0.658 (57.6% - 74.0%)
0.0003
0.612
23.1%
SNA binding
1-2a, b
63.6% (49.6% - 76.2%)
61.3% (51.4% - 70.6%)
0.659 (57.1% - 74.7%)
0.0009
0.621
24.5%
SNA/IgG index
all
66.7% (49.0% - 81.4%)
65.3% (58.1% - 72.0%)
0.706 (61.0% - 80.3%)
< 0.0001
0.651
32.1%
SNA/IgG index
0+1
69.4% (51.8% - 83.7%)
70.3% (57.6% - 81.1%)
0.754 (65.2% - 85.5%)
< 0.0001
0.700
39.1%
SNA/IgA index
all
58.3% (40.8% - 74.5%)
80.3% (74.0% - 85.7%)
0.793 (71.0% - 87.7%)
< 0.0001
0.769
49.2%
SNA/IgA index
0+1
58.3% (40.8% - 74.5%)
87.5% (76.9% - 94.5%)
0.833 (74.7% - 91.8%)
< 0.0001
0.770
62.5%
IgA avidity index
1-3a
75.0% (56.6% - 88.5%)
82.2% (74.4% - 88.3%)
79.7% (70.1% - 89.3%)
< 0.0001
0.808
33.3%
The diagnostic sensitivity, specificity, and accuracy for representative parameters studied at different stages of cancer. The area under the curve (AUC) with 95% confidence interval (CI), the accuracy of diagnostics (ACC), and P values are presented. AUC: the area under the receiver operator curve (ROC).
