Weight Loss in Parkinson’s Disease: The Relationship with Motor Symptoms and Disease Progression

Table 1

Comparison of Parkinson’s disease patients with and without weight loss.

PD patients	With WL			Without WL			p
	(n= 70)			(n= 74)			value
	Mean	±SD	Range	Mean	±SD	Range
Age (years)	67,2	8,24	43- 81	63,23	8,47	38- 82	0.004
Age at disease onset (years)	6,39	10,64	30- 74	55,8	10,08	33- 77	ns
Disease duration (years)	10,83	5,93	1- 27	7,42	5,53	1- 24	<0.001
HY stage	2,44	0,56	2- 4	2,1	0,39	1- 3	<0.001
UPDRS –III total score	25,41	9,53	5- 48	20,84	7,93	2- 44	0.006
T-subscore	3,39	3,82	0- 23	2,89	2,68	0- 17	ns
BR-subscore	14,26	5,67	2- 28	12,62	5,43	3- 29	ns
NDS-subscore	4,73	2,9	0- 12	2,72	1,93	0-8	<0.001
DK score (item 32 UPDRS-IV)	0,99	1,01	0- 3	0,5	0,84	0- 3	ns
Levodopa dose (mg/day)	706,34	250,04	300- 1350	669,9	285,59	150- 1400	ns
LEDD	920,3	419,7	100- 2390	639,6	460,4	100- 1750	<0.001

PD= Parkinson’s disease; WL= weight loss; HY= Hoehn and Yahr; UPDRS= Unified Parkinson disease rating scale; T= tremor; BR= Bradykinesia and Rigidity; NDS= non dopaminergic symptoms; DK= dyskinesias; mg= milligrams; ns= not significant; n= number of cases; LEDD= levodopa equivalent daily dose.