Maternal, Fetal, and Neonatal Outcomes in Pregnant Dengue Patients in Mexico
Table 1
Demographic, clinical, and laboratory information for a cohort of pregnant dengue patients in Mexico.
Parameters
Disease classification
P value
Dengue without warning signs
Dengue with warning signs
Severe dengue
Mean (± standard deviation)
General information
Age (years)
25.7 ± 5.4
26.5 ± 5.4
24.2 ± 5.4
0.05
Illness onset (weeks of gestation)
27.5 ± 6.1
28.2 ± 6.9
33.1 ± 5.5
0.015
Time in hospital (days)
5.9 ± 1.4
6.3 ± 2.3
9.1 ± 4.2
0.009
cPhysiological parameters
Arterial pressure (mm Hg)
55.4 ±16.8
59.2 ± 15.4
71.8 ± 23.2
0.013
Breathing rate (breaths per min.)
18.2 ±1.7
18.0 ± 0.8
19.4 ± 2.0
0.05
Heart rate (beats per min.)
91.2 ±4.4
90.2 ± 5.4
96.3 ± 15.8
0.05
c,dBlood count
Coagulation time: PT (sec) [.1–15.0]
12.8 ± 1.9
13.0 ± 0.6
15.2 ± 3.6
0.042
Coagulation time: PPT (sec) [.7–33.7]
32.5 ± 5.1
33.8 ± 3.4
52.6 ± 74.6
0.05
Hematocrit (%) [–47]
36.5 ± 2.0
35.3 ± 2.4
36.1 ± 11.8
0.018
Hemoglobin (g/dl) [–16]
11.9 ± 0.7
11.6 ± 0.7
11.0 ± 1.2
0.001
Leukocytes (×1000) (per µl) [–11]
4.3 ± 0.6
4.7 ± 0.8
5.9 ± 1.6
0.001
Platelets (×1000) (per µl) [–450]
114.0 ± 20.1
113.8 ± 15.4
82.1 ± 41.8
0.05
c,dMetabolic profile
Creatinine (mg/dL) [.5–1.5]
1.0 ± 0.3
0.8 ± 0.5
1.3 ± 0.8
0.05
Glucose (mg/dL) [–120]
91.7 ± 12.3
93.4 ± 6.2
103.2 ± 21.0
0.05
Urea (mg/dL) [.0–38.0]
16.6 ± 8.3
13.7 ± 6.5
27.0 ± 20.9
0.05
c,dHepatic profile
ALB (g/dl) [.0–5.0]
2.9 ± 0.2
4.1 ± 5.5
4.4 ± 6.8
0.000
ALT (IU/L) [–40]
54.6 ± 44.1
62.5 ± 68.1
261.9 ± 329.3
0.001
AST (IU/L) [–48]
85.6 ± 63.4
107.9 ± 125.1
469.0 ± 702.8
0.000
DB (mg/dl) [.1–0.3]
0.2 ± 0.2
0.2 ± 0.2
1.2 ± 1.3
0.000
IB (mg/dl) [.1–0.4]
0.2 ± 0.2
0.3 ± 0.2
0.8 ± 0.7
0.000
LDH (UI/L) [–280]
158.9 ± 114.0
242.9 ± 190.4
731.1 ± 752.1
0.000
One-way ANOVA test. Nonparametric Kruskal-Wallis test, determined during the acute-phase of illness, and normal ranges are provided in square brackets. ALB: albumin, ALT: alanine aminotransferase, AST: aspartate aminotransferase, DB: direct bilirubin, IB: indirect bilirubin, LDH: lactate dehydrogenase, PT: Prothrombin time, and PPT: Prothrombin partial time.
