Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer

Table 2

The therapeutic theory of different sources of MSCs.

BMMSCs	ADMSCs	UCBMSCs	UCMSCs	TDMSCs	AMSCs	AFSC
↑ Treg cells	↑ Treg cells	↑ Treg cells	↑ Treg cells	↓CD3+T cells	↓Macrophage	↑ Treg cells
↑ Th2 cells	↑ Th2 cells	↑ Th2 cells	↑ Th2 cells	(↑apoptosis	(M1→M2)	↑ Th2 cells
↓ Th1 cells	↓ Th1 cells	↓ Th1 cells	↓ Th1 cells	↓proliferation)	↓ Neutrophils	↓ Th1 cells
↓ Th17 cells	↓ Th17 cells	↓ Th17 cells	↓ Th17 cells			↓ Th17 cells
↓Macrophage (M1→M2)	↓Macrophage	regulate tight junction proteins	↓CD3+T cells			↑ COXs
↓ Neutrophils	(M1→M2)	↓ monocyte	(↑apoptosis
↑ MDSCs	↓oxidative stress	↓CD3+T cells activation	↓proliferation)
↓CD3+T cells	↓cell senescence		↓ Neutrophils
(↑apoptosis ↓proliferation)	↑wound repair		↑ CD5+ B cells
↓oxidative stress			↑ CD5+ Bregs
↓cell senescence
↓mucosal permeability
↑neuroprotective

MDSCs: myeloid derived suppressor cells.