Table 2: The therapeutic theory of different sources of MSCs.

BMMSCsADMSCsUCBMSCsUCMSCsTDMSCsAMSCsAFSC

↑ Treg cells↑ Treg cells↑ Treg cells↑ Treg cells↓CD3+T cells↓Macrophage↑ Treg cells
↑ Th2 cells↑ Th2 cells↑ Th2 cells↑ Th2 cells(↑apoptosis(M1→M2)↑ Th2 cells
↓ Th1 cells↓ Th1 cells↓ Th1 cells↓ Th1 cells↓proliferation)↓ Neutrophils↓ Th1 cells
↓ Th17 cells↓ Th17 cells↓ Th17 cells↓ Th17 cells↓ Th17 cells
↓Macrophage (M1→M2)↓Macrophageregulate tight junction proteins↓CD3+T cells↑ COXs
↓ Neutrophils(M1→M2)↓ monocyte(↑apoptosis
↑ MDSCs↓oxidative stress↓CD3+T cells activation↓proliferation)
↓CD3+T cells↓cell senescence↓ Neutrophils
(↑apoptosis ↓proliferation)↑wound repair↑ CD5+ B cells
↓oxidative stress↑ CD5+ Bregs
↓cell senescence
↓mucosal permeability
↑neuroprotective

MDSCs: myeloid derived suppressor cells.