| | No. of patients | OR (95%CI) | P value |
| Age, year | | | | 18-68.2 | 7014 | 1.07 (1.02, 1.13) | 0.0080 | 68.3-91.4 | 7064 | 1.07 (1.02, 1.13) | 0.0055 | Gender | | | | F | 5992 | 1.08 (1.02, 1.14) | 0.0043 | M | 8086 | 1.05 (1.00, 1.10) | 0.0657 | CHF | | | | No | 11643 | 1.08 (1.04, 1.12) | 0.0002 | Yes | 2435 | 1.04 (0.95, 1.14) | 0.3920 | AKI stage | | | | Stage 1 | 2395 | 1.12 (1.01, 1.24) | 0.0268 | Stage 2 | 2707 | 1.09 (1.00, 1.18) | 0.0444 | Stage 3 | 8976 | 1.06 (1.01, 1.10) | 0.0119 | AF | | | | No | 9459 | 1.08 (1.03, 1.12) | 0.0011 | Yes | 4619 | 1.06 (0.99, 1.12) | 0.0830 | COPD | | | | No | 13721 | 1.07 (1.03, 1.11) | 0.0002 | Yes | 357 | 1.01 (0.77, 1.32) | 0.9696 | CAD | | | | No | 9856 | 1.07 (1.03, 1.11) | 0.0004 | Yes | 4222 | 1.03 (0.94, 1.12) | 0.5476 | Stroke | | | | No | 12542 | 1.09 (1.05, 1.13) | <0.0001 | Yes | 1536 | 1.04 (0.92, 1.17) | 0.4969 | Respiratory failure | | | | No | 8298 | 1.02 (0.96, 1.09) | 0.4467 | Yes | 5780 | 1.09 (1.04, 1.14) | 0.0002 | Pneumonia | | | | No | 9966 | 1.06 (1.01, 1.11) | 0.0170 | Yes | 4112 | 1.08 (1.02, 1.14) | 0.0076 | ARDS | | | | No | 13778 | 1.07 (1.03, 1.11) | 0.0003 | Yes | 300 | 1.00 (0.80, 1.26) | 0.9832 | Liver | | | | No | 13174 | 1.08 (1.04, 1.12) | 0.0001 | Yes | 904 | 1.01 (0.93, 1.11) | 0.7745 | Vasoactive drug | | | | No | 6993 | 1.04 (0.98, 1.10) | 0.2382 | Yes | 7085 | 1.09 (1.04, 1.14) | 0.0001 | RRT | | | | No | 12938 | 1.09 (1.05, 1.13) | <0.0001 | Yes | 1140 | 0.97 (0.89, 1.06) | 0.4664 | SIRS | | | | 0 | 104 | 1.28 (0.81, 2.00) | 0.2891 | 1 | 887 | 1.27 (1.13, 1.42) | <0.0001 | 2 | 2952 | 1.27 (1.20, 1.35) | <0.0001 | 3 | 5486 | 1.26 (1.21, 1.31) | <0.0001 | 4 | 4873 | 1.20 (1.15, 1.24) | <0.0001 |
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