Development of Nanoemulsions to Enhance the Antileishmanial Activity of Copaifera paupera Oleoresins

Table 4

In vitro activity of the nanoemulsions containing oleoresins (NANORE04, NANORB13), fraction rich in kaurene (NANODITB13), and α-copaene (NANOCOPAEN) against L. amazonensis and L. infantum.

	Blank; (empty nano)	NANORE04; IC50 (μg/mL)	NANORB13; IC50 (μg/mL)	NANODITB13; IC50 (μg/mL)	NANOCOPAEN; IC50 (μg/mL)
L. amazonensis	n.a.	17.3 ± 2.1	34.7 ± 10.4	28.9 ± 3.7	2.5 ± 1.2
L. infantum	n.a.	39.8 ± 0.3	46.8 ± 8.8	54.7 ± 6.0	2.2 ± 0.8

IC₅₀ expressed as μg/mL ± standard error, ; n.a.: not active.