Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer

Table 1

Correlation of S100 member expression with smoking status of NSCLC patients. Expression of S100A2, S100A7, S100A8, S100A9, S100A11, and S100A12 correlated with smoking status of NSCLC patients; S100A5, S100A6, S100A13, S100A16, and S100G were associated worse survival in nonsmoking NSCLC patients; and only S100B, but S100A14 and S100P, was associated with better survival in smoking NSCLC patients.

S100 family	Affymetrix IDs	Smoking status	HR	95% CI	value
S100A1	205334_at	Never smoked	2.1	(1.17, 3.77)	0.0110
		Smoked	1.21	(0.98, 1.48)	0.0750
S100A2	204268_at	Never smoked	4.1	(2.1, 8)	0.0000
		Smoked	1.47	(1.19, 1.81)	0.0003
S100A3	206027_at	Never smoked	1.91	(1.07, 3.38)	0.0250
		Smoked	1.15	(0.93, 1.41)	0.2000
S100A4	203186_s_at	Never smoked	2.06	(1.14, 3.7)	0.0140
		Smoked	1.23	(1, 1.51)	0.0500
S100A5	207763_at	Never smoked	2.73	(1.47, 5.07)	0.0009
		Smoked	1.13	(0.92, 1.39)	0.2400
S100A6	217728_at	Never smoked	3.53	(1.87, 6.65)	0.0000
		Smoked	1.29	(1.05, 1.59)	0.0160
S100A7	205916_at	Never smoked	4.37	(2.35, 8.11)	0.0000
		Smoked	1.34	(1.09, 1.65)	0.0053
S100A7A	232170_at	Never smoked	1.12	(0.5, 2.5)	0.7800
		Smoked	1.55	(1.03, 2.34)	0.0330
S100A8	202917_s_at	Never smoked	2.86	(1.54, 5.3)	0.0005
		Smoked	1.76	(1.42, 2.17)	0.0000
S100A9	203535_at	Never smoked	3.18	(1.71, 5.9)	0.0001
		Smoked	1.55	(1.26, 1.91)	0.0000
S100A10	200872_at	Never smoked	1.66	(0.93, 2.94)	0.0810
		Smoked	1.22	(0.99, 1.5)	0.0620
S100A11	200660_at	Never smoked	4	(2.09, 7.67)	0.0000
		Smoked	1.36	(1.11, 1.68)	0.0033
S100A12	205863_at	Never smoked	2.76	(1.5, 5.05)	0.0006
		Smoked	1.37	(1.11, 1.69)	0.0028
S100A13	202598_at	Never smoked	3.32	(1.79, 6.16)	0.0001
		Smoked	1.16	(0.94, 1.43)	0.1600
S100A14	218677_at	Never smoked	1.8	(1.02, 3.2)	0.0410
		Smoked	1.31	(1.07, 1.62)	0.0098
S100A16	227998_at	Never smoked	5.12	(1.75, 14.99)	0.0009
		Smoked	1.29	(0.85, 1.95)	0.2300
S100B	209686_at	Never smoked	0.77	(0.44, 1.35)	0.3700
		Smoked	0.71	(0.58, 0.87)	0.0012
S100G	207885_at	Never smoked	2.93	(1.62, 5.31)	0.0002
		Smoked	1.25	(1.02, 1.54)	0.0340
S100P	204351_at	Never smoked	1.22	(0.7, 2.15)	0.4800
		Smoked	1.38	(1.12, 1.7)	0.0022
S100Z	1554876_a_at	Never smoked	0.82	(0.37, 1.83)	0.6300
		Smoked	1.21	(0.81, 1.82)	0.3500