BioMed Research International / 2018 / Article / Fig 3

Review Article

Onco-Multi-OMICS Approach: A New Frontier in Cancer Research

Figure 3

Proteomics and phosphoproteomics driven identification of the aberrant regulation of signalling pathways leading to poor patient survival. (a) Aberrant PDGFRB signalling pathway induces angiogenesis in patients and results in poor survival. Phosphorylated and unphosphorylated forms of proteins are indicated by blue and orange color. The directions of arrows indicate the regulation—up and down arrows indicate upregulation and downregulation, respectively. Colors of the arrows indicate the phosphoform or the total protein detected by (phospho)proteomics experiments. Blue and red arrows indicate phospho- and total protein, respectively. (b) Integrin-linked kinase pathway induces cell mobility and invasion, leading to poor patient survival. Two signalling pathways, MAPK (green) and PI3K (purple), are highlighted. Both these pathways were found to be upregulated in cancer patients with poor survival.

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