Microsurgical Reconstruction of the Jaws Using Vascularised Free Flap Technique in Patients with Medication-Related Osteonecrosis: A Systematic Review

Table 10

Complications during follow-up time.

Study	Follow-up time	Complications during follow-up (included plate removal)	MRONJ recurrence	Site of recurrence
Engroff and Kim (2007) [28]	2x12 months	0	Recurrence in one patient	Contralateral
Ferrari et al. (2008) [29]	1 x 12 months	Plate removal	0	0
Mücke et al. (2009) [30]	2x 12 months	0	0	0
Nocini et al. (2009) [31]	1x 6 months; 1 x 16 months; 1 x 23 months; 1 x 24 months; 1 x 19 months; 1 x 33 months; 1 x 34 months	0	Recurrence in one patient	Margin of the resection
Seth et al. (2010) [32]	1 x 10.0 months; 1x 0.5 months; 1x 30.8 months; 1x 21.4 months; 1x 17.8 months; 1x 23.7 months; 1x 10.6 months; 1 x 14.2 months; 1x 13.9 months; 1x 12.2 months; 1x 6.1 months	0	0	0
Bedogni et al. (2011) [33]	NR	failure of the FFF 1 year later	0	0
Pautke et al. (2011) [34]	NR	plate removal	Recurrence in one patient	On the free flap
Bittner et al. (2012) [35]	NR	0	0	0
Ghazali et al. (2013) [36]	24 months	0	0	0
Hanasono et al. (2013) [37]	1 x 13.3 months; 1x 20.1 months; 1x 77.0 months; 1x 23.8 months; 1x 11.4 months; 1 x 9.1 months; 1x 9.1 months; 1x 9.1 months; 1x 8.1 months; 2 x 3.0 months	0	0	0
Horta et al. (2014) [38]	1 x 12 months	0	0	0
Spinelli et al. (2014) [39]	1x 21.7 months; 1x 25.1 months; 1x 28.4 months; 1x 32.2 months; 1x 37 months; 1x 28.4 months; 1x 25.1 months; 1x 32.9 months	0	0	0
Vercruysse et al. (2014) [25]	1x 36 months; 1x 65 months; 1x 76 months	Plate removal in one patient	Recurrence in one patient	Contralateral
Kim et al. (2015) [40]	1 x 99 months; 1 x 18 months; 1 x 12 months; 1 x 7 months	Fracture of plate in one patient	0	0
Mücke et al. (2016) [41]	34.25 ± 33.3 months	-	Recurrence in one of the patient	Margin of the flap
Neto et al. (2016) [26]	1 x 48 months	0	0	0
Sotsuka et al. (2016) [42]	NR	0	0	0
Caldroney et al. (2017) [43]	3 x 6 months; 2 x 44 months; 1 x 69 months; 1 x 36 months; 1 x 28 months; 1 x 10 months; 1 x 17 months; 1 x 11 months	Plate removal in one patient	0	0