Microsurgical Reconstruction of the Jaws Using Vascularised Free Flap Technique in Patients with Medication-Related Osteonecrosis: A Systematic Review

Table 8

Preoperative epidemiologic analysis (age, sex, predisposing factors, and site of the necrosis involved). M: male; F: female; NR: not reported.

Study	Type of study	Patients number	Age/Sex	Trigging cause	Site of the necrosis involved
Engroff and Kim (2007) [28]	Case series	2	64 (F); 49 (F)	Dental extraction (x 2 cases)	Mandible (x 2 cases)
Ferrari et al. (2008) [29]	Case report	1	66 (M)	NR	Mandible
Mücke et al. (2009) [30]	Case series	2	48 (F); 60 (F)	Dental Extraction (x 1 case); Spontaneous (x 1 case)	Mandible (x 2 cases)
Nocini et al. (2009) [31]	Case series	7	NR (six F); (one M)	Oral surgery (x 5 cases); Infection (x 2 cases)	Mandible (x 7 cases)
Seth et al. (2010) [32]	Case series	11	68 (M); 56 (F); 50 (F); 72 (F); 48 (F); 71 (F); 67 (F); 60 (F); 51 (F); 72 (M); 60 (F)	NR	Mandible (x 11 cases)
Bedogni et al. (2011) [33]	Case series	3	NR	NR	Mandible (x 2 cases); Maxilla (x 1 case)
Pautke et al. (2011) [34]	Case report	1	76 (M)	Dental extraction	Mandible
Bittner et al. (2012) [35]	Case report	1	41 (F)	Dental extraction	Mandible
Ghazali et al. (2013) [36]	Case report	1	82 (F)	Dental extraction	Mandible
Hanasono et al. (2013) [37]	Case series	11	63 (F); 57 (M); 65 (M); 75 (F); 72 (M); 68 (M); 60 (F); 64 (F); 70 (F); 75 (F); 67 (F)	NR	Mandible (x 11 cases)
Horta et al. (2014) [38]	Case series	1	54 M	Spontaneous	Mandible
Spinelli et al. (2014) [39]	Case series	8	73 (M); 77 (F); 64 (F); 53 (F); 62 (M); 68 (F); 57 (M); 64 (F)	Dental extraction (x 3 cases); Spontaneous x 5	Mandible (x 8 cases)
Vercruysse et al. (2014) [25]	Case series	3	54 (F); 70 (F); 64 (F)	Dental extraction (x 1 case); Spontaneous (x 2 cases)	Mandible (x 3 cases)
Kim et al. (2015) [40]	Case series	4	69 (F), 68 (F), 62 (F), 70 (M)	NR	Mandible (x 4)
Mücke et al. (2016) [41]	Case series	14	NR	NR	Mandible (x 14 cases)
Neto et al. (2016) [26]	Case report	1	58 (M)	Spontaneous	Mandible
Sotsuka et al. (2016) [42]	Case report	1	50 (F)	NR	Maxilla
Caldroney et al. (2017) [43]	Case series	11	56 (F); 65 (F); 60 (F); 61 (F); 65 (F); 64 (F); 68 (M); 67 (M); 73 (M); 72 (F); 73 (M).	NR	Mandible (x 11 cases)