Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
Table 1
Comparison of the number of differentially expressed genes during skin development in mice (p<0.10, fold>2.0) based on real-time qPCR and on exon array analysis.
Total genes
System
E14 vs. P90
E16 vs. P90
P1 vs. P90
Down
Up
Down
Up
Down
Up
Production of precursors
43
TLDA
1
4
3
2
1
2
43
Exon
2
6
2
0
1
0
Overlap
0
2
2
0
1
0
Core proteins
14
TLDA
2
3
1
1
2
2
14
Exon
3
2
1
1
0
2
Overlap
2
2
0
1
0
2
Preparation of linkage region
8
TLDA
0
1
0
1
0
1
8
Exon
0
2
0
0
0
0
Overlap
0
0
0
0
0
0
Glycosaminoglycan chain polymerisation
13
TLDA
1
4
1
2
0
2
13
Exon
1
2
0
0
0
0
Overlap
0
0
0
0
0
0
Glycosaminoglycan chain modification
32
TLDA
1
9
0
5
0
8
32
Exon
1
3
0
3
0
1
Overlap
1
2
0
1
0
0
Glycosaminoglycan chain degradation
19
TLDA
2
2
3
1
0
1
19
Exon
3
1
1
1
2
0
Overlap
2
1
1
1
0
0
Growth factors
37
TLDA
0
13
3
8
1
11
37
Exon
2
14
3
10
1
4
Overlap
0
10
2
8
0
4
P values for the exon array measurements were calculated using Benjamini–Hochberg multitesting correction. P values for the TLDA assay were calculated using an unpaired T-test. Overlap refers to genes differentially expressed in both TLDA card and exon array.
