BioMed Research International

Research Article

Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development

Table 4

Differentially expressed genes in C5 epimerase (Glce) knockout mouse (p<0.10) based on real-time qPCR.


Gene symbol	Full gene name and probe set	P-value	Relative change

*Production of precursors*
Gnpnat1	Glucosamine-Phosphate N-Acetyltransferase 1	*0.033*	*0.468*
	Mm00834602_mH
Slc2a4	Solute Carrier Family 2 Member 4	*0.086*	*2.526*
	Mm01245507_g1
*Core proteins*
Acan	Aggrecan	*0.005*	*0.242*
	Mm00545807_m1
Aspn	Asporin	*0.010*	*0.382*
	Mm00445945_m1
*Glycosaminoglycan chain polymerisation*
Csgalnact	CS N-Acetylgalactosaminyltransferase 2	*0.049*	*0.431*
2	Mm00513340_m1
*Glycosaminoglycan chain modification*
Glce	Glucuronic Acid Epimerase	*0.013*	*0.079*
	Mm00473667_m1

Numbers in Italic are significant (p<0.10); numbers in bold are >2 fold differentially expressed.
All genes were normalized using 18S RNA as a reference gene.