Effects of Diacetyl Flavoring Exposure in Mice Metabolism
Table 2
Plasma metabolite concentrations from female and male groups treated with 300 mg/kg/day of diacetyl for 15 weeks.
Metabolite
Control Female
300 mg/kg/day Female
Control Male
300 mg/kg/day Male
5-HT
0.87 ± 0.03
1.33 ± 0.03 (↑)
1.27 ± 0.03
6.83 ± 0.03 (↑)
Ac-Orn
4.37 ± 0.70
11.00 ± 3.10 (↑)
2.97 ± 0.03
4.13 ± 0.03 (↔)
ADMA
63.00 ± 2.00
104.00 ± 2.35 (↑)
0.6 ± 0.11
0.57 ± 0.03 (↔)
ALA
215.00± 4.23
706.00 ± 5.78 (↑)
240.15 ± 4.20
421,00 ± 3.72 (↑)
Arg
70.00 ± 1.47
122.00 ± 1.54 (↑)
75.00 ± 1.86
114.00 ± 3.47 (↑)
Asn
110.00 ± 4.25
449.0 ± 12.08 (↑)
30 ± 0.81
65.0 ± 1.46 (↑)
Asp
197.00 ± 13.90
97.00 ± 12.77 (↓)
16.00 ± 1.90
18.00 ± 2.70 (↔)
Car
51.0 0± 0.73
146.00 ± 3.02 (↑)
0.97 ± 0.03
0.70 ± 0.06 (↑)
Cit
6.83 ± 0.68
26.00 ± 0.63 (↑)
40.00 ± 0.94
66.00 ± 0.70 (↑)
Cre
8667.00 ± 654.00
8642.00 ± 7370.00 (↔)
19.00 ± 1.01
8.20 ±11.00 (↓)
Dopa
0.87 ± 0.03
0.93 ± 0.03 (↔)
0.70 ± 0.00
0.43 ± 0.30 (↓)
Gln
239.00 ± 6.56
1898.00 ± 61.40 (↑)
485.00 ± 15.40
760.00 ± 15.10 (↑)
Glu
136.00 ± 8.50
111.00 ± 5.40 (↓)
62.00 ± 3.44
93.00 ± 10.50 (↑)
Gly
439.00 ± 15.60
1988.00 ± 11.00 (↑)
56.00 ± 4.07
82.00 ± 3.09 (↑)
His
439.00 ± 2.96
1988.00 ± 27.40 (↑)
56.00 ± 0.20
82.00 ± 1.31 (↑)
Hst
0.30 ± 0.00
0.50 ± 0.00 (↑)
1.43 ± 0.03
0.97 ± 0.03 (↓)
Ile
19.00 ± 0.20
36.00 ± 1.15 (↑)
66.00 ± 0.79
114.00 ± 0.55 (↑)
Kyn
22.00 ± 0.30
27.00 ± 0.52 (↑)
2.07.0 ± 0.10
0.8 ± 0.00 (↓)
Leu
33.00 ± 9.87
63.00 ± 11.70 (↑)
113.0 ± 9.17
213.00 ± 4.50 (↑)
Lys
73.00 ± 3.69
106.00 ± 38.00 (↑)
182.00 ± 4.05
348.0 ± 1.07 (↑)
Met
6.80 ± 0.06
18.00 ± 0.55 (↑)
33.00 ± 0.72
50.00 ± 0.35 (↑)
Met-SO
0.80 ± 0.26
26.00 ± 0.20 (↑)
2.57 ± 0.24
2.77 ± 0.12 (↔)
Orn
17.00 ± 1.74
11.00 ± 2.33 (↓)
60.0 ± 0.17
120.00 ± 0.68 (↑)
Phe
118.00 ± 1.23
203.00 ± 2.59 (↑)
71.00 ± 0.95
93.00 ± 0.19 (↑)
Pro
12.00 ± 0.22
46.00 ± 0.72 (↑)
69.00 ± 0.26
108.00 ± 2.13 (↑)
Put
6.07 ± 0.52
7.05 ± 0.37 (↔)
0.73 ± 0.07
1.13 ± 0.03 (↓)
Sar
12.00 ± 0.48
41.00 ± 2.29 (↑)
14.00 ± 0.76
26.00 ± 0.96 (↑)
T4-OH-Pro
14.00± 1.41
1.87 ± 0.22 (↓)
0.87 ± 0.07
0.5 ± 0.32 (↔)
Tau
58.00 ± 4.33
186.00 ± 3.50 (↑)
208.00 ± 1.70
329.00 ± 2.89 (↑)
Thr
75.00 ± 0.92
382.00 ± 0.41 (↑)
101.00 ± 2.14
138.00 ± 2.89 (↑)
Trp
69.00 ± 0.43
192.00 ± 0.58 (↑)
90.00 ± 0.20
81.00 ± 0.58 (↓)
Tyr
148.00 ± 3.04
297.00 ± 0.21 (↑)
69.00 ± 1.79
96.0 ± 1.41 (↑)
Val
47.00 0.22
99.00 1.35 ()
155.00 2.44
240.00 2.90 ()
↑ significant increase in concentration compared to respective control group; ↓ significant decrease in concentration compared to respective control group; ↔ concentration does not have significant difference from control group.
