Ghrelin Ameliorates Angiotensin II-Induced Myocardial Fibrosis by Upregulating Peroxisome Proliferator-Activated Receptor Gamma in Young Male Rats

Figure 3

Ghrelin lowered systolic blood pressure and collagen I and collagen III protein expression in the myocardium of Ang II-infused rats. (a) Blood pressure tested weekly in control, Ang II, Ang II +Ghrelin, Ang II +Ghrelin +GW9662, Ang II + GW9662, and Ghrelin and Ang II + hydralazine groups by the tail-cuff method. (b) Collagen I and collagen III protein expression in control, Ang II, Ang II +Ghrelin, and Ang II + hydralazine groups. (c and d) Quantitative analysis of (b). Results are expressed as mean ± SEM, n = 6 each per group. p<0.05 versus Control; #p<0.05 versus Ang II; ^&p<0.05 versus Ang II+Ghrelin.

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