Galphimine-B Standardized Extract versus Alprazolam in Patients with Generalized Anxiety Disorder: A Ten-Week, Double-Blind, Randomized Clinical Trial
Table 2
Effect produced by oral administration for 10 weeks of a Galphimine-B (G-B) standardized extract (experimental group) or Alprazolam (control group) on perception of mental health status in patients diagnosed with Generalized Anxiety Disorder (GAD) included in the study. The data were obtained through a self-evaluation by means of a Health Scale.
Experimental group/Control group
Variable
2 weeks
4 weeks
6 weeks
8 weeks
10 weeks
n 76 / 61
n 62/58
n 69/71
n 63/62
69/64
F / (%)
F / (%)
F / (%)
F / (%)
F / (%)
Perception of the patient’s health
Excellent
4(5.3) / 1(1.6)
4(6.5) / 4(6.8)
8(11.5) / 14(19.7)
19(30.1) / 16(25.8)
30(43.4) / 23(35.9)
Very good
9(11.8) / 13(21.3)
13(20.9) / 11(18.9)
29(42) / 18(25.3)
21(33.3) / 23(37)
21(30.4) / 23(35.9)
Good
35(46) / 23(37.7)
34(54.8) / 32(55.1)
24(34.7) / 25(35.2)
16(25.3) / 18(29)
11(15.9) / 14(21.8)
Fair
26(34.3) / 23(37.7)
11(17.7) / 11(18.9)
8(11.5) / 13(18.3)
5(7.9) / 4(6.4)
7(10.1) / 4(6.5)
Poor
2(2.6) / 1(1.6)
0(0) / 0(0)
0(0) / 1(1.4)
2(3.1) / 1(1.6)
0(0) / 0(0)
Person X2/p
3.93 / 0.41
0.29 / 0.96
6.99 / 0.22
0.90 / 0.92
2.00 / 0.57
After your last physician visit, did your condition make it difficult for you to work inside or outside the home?
No
53(69.8) / 26(42.6)
40(64.5) / 33(56.8)
52(75.4) / 39(54.9)
48(76.2) / 43(69.3)
55(79.7) / 44(68.7)
A little bit
21(27.7) / 22(36)
17(27.4) / 18(31)
16(23.2) / 27(38)
15(23.8) / 16(25.8)
14(20.2) / 16(25)
A fair amount
2(2.6) / 6(9.8)
5(8) / 6(10.3)
1(1.5) / 5(7)
0(0) / 2(3.2)
(0) / 3(4.6)
Fairly
0(0) / 3(4.9)
0(0) / 1(1.7)
0(0) / (0)
0(0) / 0(0)
(0) / 1(1.5)
Quite a lot
0(0) / 4(6.5)
0(0) / (0)
0(0) / (0)
0(0) / 1(1.6)
(0) / (0)
Person X2/p
16.81 / 0.002
1.65 / 0.64
7.31 / 0.02
3.29 / 0.34
5.17 / 0.15
Did you stop engaging in daily activities because of sadness, nervousness or depression?
No
50(65.7) / 28(45.9)
44(70.9) / 32(55.1)
51(73.9) / 40(56.3)
47(74.6) / 42(67.7)
54(78.6) / 47(73.4)
A little bit
19(25) / 19(31.1)
15(24.1) / 16(27.5
17(24.6) / 28(39.4)
15(23.8) / 18(29)
14(20.2) / 16(25)
A fair amount
4(5.2) / 7(11.4)
3(4.8) / 9(15.5)
1(1.4) / 3(4.2)
1(1.5) / 1(1.6)
1(1.4) / 0(0)
Fairly
2(2.6) / 4(6.5)
0(0) / 1(1.7)
0(0) / 0(0)
0(0 ) / 1(1.6)
0(0) / 1(1.5)
Quite a lot
1(1.3) / 3(4.9)
0(0) / 0(0)
0(0) / 0(0)
0(0) / (0)
0(0) / (0)
Person X2/p
7.13 / 0.12
5.8 / 0.12
4.99 / 0.08
1.54 / 0.67
2.4 / 0.48
Did you take less care in your daily activities due to sadness, nervousness, or depression?
No
52(68.4) / 24(39.3)
43(69.3) / 34(58.6)
51(73.9) / 42(69.3)
49(77.7) / 43(69.3)
53(76.8) / 45(70.3)
A little bit
17(22.4) / 23(37.7)
16(25.8) / 16(27.5)
17(20.6) / 25(27.5)
13(20.6) / 17(27.5)
15(21.7) / 18(28.1)
A fair amount
2(2.6) / 8(13.1)
3(4.8) / 7(12)
1(1.5) / 4(5.6)
1(1.5) / 1(1.7)
1(1.4) / 0(0)
Fairly
3(3.9) / 2(3.2)
0(0) / 1(1.8)
0(0) / 0(0)
0(0) / 0(0)
0(0) / 1(1.5)
Quite a lot
0(0) / 1(1.6)
0(0) / 0(0)
0(0) / 0(0)
0(0) / 1(1.7)
0(0) / 0(0)
Person X2/p
14.7 / 0.01
3.52 / 0.31
4.16 / 0.12
1.91 / 0.59
2.74 / 0.43
After your last physician visit, how long did you feel calm and peaceful?
Always
17(22.3) / 25(40.9)
13(20.9) / 15(25.8)
29(42) / 21(29.6)
29(46.7) / 23(37)
46(66.7) / 39(60.9)
Nearly always
29(38.3) / 21(34.4)
33(53.2) / 25(43.2)
30(43.4) / 32(45)
22(34.9) / 31(50)
14(20.2) / 21(32.8)
Often
8(10.5) / 5(8.3)
4(6.5) / 5(8.6)
5(7.3) / 9(12.6)
5(7.9) / 3(4.8)
3(4.4) / 0(0)
Some-times
22(28.9) / 10(16.3)
13(20.9) / 13(22.3)
5(7.3) / 9(12.6)
7(11.1) / 5(8.2)
6(8.7) / 4(6.2)
Never
0(0) / 0(0)
0(0) / 0(0)
0(0) / (0)
0(0) / 0(0)
0(0) / (0)
Person X2/p
6.83 / 0.14
2.22 / 0.69
5.38 / 0.25
3.04 / 0.38
5.19 / 0.15
After your last physician visit, did you feel discouraged and sad?
