CDK1, CCNB1, CDC20, BUB1, MAD2L1, MCM3, BUB1B, MCM2, and RFC4 May Be Potential Therapeutic Targets for Hepatocellular Carcinoma Using Integrated Bioinformatic Analysis

Table 4

Significant changes of candidate genes expression in transcription level in HCC.

Gene ID	Types of liver cancer versus normal	-value	-test	Fold change	References
CDK1	Hepatocellular carcinoma vs. normal	6.41E−29	13.87	4.148	Chen Liver [12]
	Hepatocellular carcinoma vs. normal	1.05E−84	28.109	5.573	Roessler Liver 2 [13]
	Hepatocellular carcinoma vs. normal	5.74E−10	7.891	8.68	Wurmbach Liver [14]
	Hepatocellular carcinoma vs. normal	9.36E−10	9.077	5.808	Roessler Liver [13]
CCNB1	Hepatocellular carcinoma vs. normal	6.06E−14	10.729	10.827	Wurmbach Liver [14]
	Hepatocellular carcinoma vs. normal	3.45E−88	30.468	5.783	Roessler Liver 2 [13]
	Hepatocellular carcinoma vs. normal	5.31E−08	7.428	3.901	Roessler Liver [13]
CDC20	Hepatocellular carcinoma vs. normal	5.17E−09	7.377	5.143	Wurmbach Liver [14]
	Hepatocellular carcinoma vs. normal	1.15E−64	22.985	3.814	Roessler Liver 2 [13]
	Hepatocellular carcinoma vs. normal	6.16E−08	7.171	3.661	Roessler Liver [13]
BUB1	Hepatocellular carcinoma vs. normal	1.57E−08	7.113	4.186	Wurmbach Liver [14]
	Hepatocellular carcinoma vs. normal	2.37E−15	8.643	2.808	Chen Liver [12]
	Hepatocellular carcinoma vs. normal	5.27E−07	6.531	2.046	Roessler Liver [13]
	Hepatocellular Carcinoma vs. Normal	1.35E−46	17.257	2	Roessler Liver 2 [13]
MAD2L1	Hepatocellular carcinoma vs. normal	6.77E−20	10.263	2.43	Chen Liver [12]
	Hepatocellular carcinoma vs. normal	3.63E−56	20.301	2.884	Roessler Liver 2 [13]
	Hepatocellular carcinoma vs. normal	2.40E−07	6.715	2.548	Roessler Liver [13]
	Hepatocellular carcinoma vs. normal	3.52E−06	5.131	3.669	Wurmbach Liver [14]
MCM3	Hepatocellular carcinoma vs. normal	5.67E−72	23.777	3.023	Roessler Liver 2 [13]
	Hepatocellular carcinoma vs. normal	1.45E−08	7.55	2.953	Roessler Liver [13]
BUB1B	Hepatocellular Carcinoma vs. Normal	1.29E−11	8.907	6.747	Wurmbach Liver [14]
	Hepatocellular carcinoma vs. normal	4.52E−10	9.2	4.407	Roessler Liver [13]
	Hepatocellular carcinoma vs. normal	4.23E−64	22.98	3.34	Roessler Liver 2 [13]
	Hepatocellular Carcinoma vs. Normal	1.94E−08	5.795	2.55	Chen Liver [12]
MCM2	Hepatocellular carcinoma vs. normal	2.68E−64	21.853	3.144	Roessler Liver 2 [13]
	Hepatocellular Carcinoma vs. Normal	3.00E−08	7.289	3.252	Roessler Liver [13]
RFC4	Hepatocellular carcinoma vs. normal	1.15E−88	28.334	4.6	Roessler Liver 2 [13]
	Hepatocellular carcinoma vs. normal	5.28E−19	9.909	2.031	Chen Liver [12]
	Hepatocellular carcinoma vs. normal	4.58E−08	7.428	3.315	Roessler Liver [13]