CDK1, CCNB1, CDC20, BUB1, MAD2L1, MCM3, BUB1B, MCM2, and RFC4 May Be Potential Therapeutic Targets for Hepatocellular Carcinoma Using Integrated Bioinformatic Analysis

Table 5

Relationship between selected up-regulated genes and clinical features in HCC.

		CDK1		CCNB1		CDC20		B UB1		MAD2L1		MCM3		BUB1B		MCM2		RFC4
Item		Statistic	-value	Statistic	-value	Statistic	-value	Statistic	-value	Statistic	-value	Statistic	-value	Statistic	-value	Statistic	-value	Statistic	-value
years_to_birth (Spearman’s correlation)	340	−0.16	0.00	−0.09	0.09	−0.09	0.11	−0.09	0.09	−0.04	0.43	−0.11	0.04	−0.12	0.03	−0.10	0.07	−0.12	0.02
Tumor_purity (Spearma’s correlation)	343	−0.01	0.82	−0.02	0.70	−0.06	0.24	−0.05	0.32	−0.09	0.08	0.09	0.10	−0.01	0.85	0.02	0.76	0.00	0.99
overall_survival (Cox regression test)	alive 220	0.26	0.00	0.34	0.00	0.29	0.00	0.25	0.00	0.34	0.00	0.32	0.00	0.24	0.00	0.31	0.00	0.37	0.00
	dead 123
pathologic_stage (Kruskal-Wallis test)	stage I 161	19.14	0.00	21.37	0.00	19.04	0.00	23.47	0.00	23.03	0.00	16.08	0.00	22.74	0.00	13.83	0.00	14.63	0.00
	stage II 77
	stage III 80
	stage IV 3
race (Kruskal-Wallis test)	american Indian or alaska native 1	13.12	0.00	15.19	0.00	14.12	0.00	7.51	0.06	1.05	0.79	20.12	0.00	10.93	0.01	17.21	0.00	21.99	0.00
	asian 148
	Black or arican american 15
	white 169
pathology_T_stage (Kruskal-Wallis test)	t1 168	17.25	0.00	20.33	0.00	19.96	0.00	23.64	0.00	24.03	0.00	14.16	0.00	19.89	0.00	12.42	0.01	11.72	0.01
	t2 84
	t3 75
	t4 13
pathology_N_stage (Wilcox test)	n0 239	0.09	0.20	−0.01	0.91	0.15	0.67	0.09	0.28	0.20	0.09	0.03	0.35	0.17	0.18	0.14	0.58	0.11	0.26
	n1 3
pathology_M_stage (Wilcox test)	m0 245	−0.14	0.24	−0.13	0.29	−0.17	0.26	−0.26	0.17	−0.09	0.36	−0.11	0.24	−0.37	0.10	−0.07	0.27	−0.11	0.18
	m1 3
histological_type (Kruskal–Wallis test)	fibrolamellar carcinoma 2	1.65	0.44	2.51	0.29	2.2	0.33	2.89	0.24	2.76	0.25	3.94	0.14	2.23	0.33	3.28	0.19	2.40	0.30
	hepatocellular carcinoma 336
	hepatocholang-iocarcinoma 5
radiation_therapy (Wilcox test)	no 323	−0.07	0.59	0.02	0.80	0.03	0.98	−0.15	0.25	−0.01	0.54	−0.06	0.47	−0.14	0.24	−0.06	0.39	0.00	0.92
	yes 9
residual_tumor (Kruskal-Wallis test)	r0 303	1.58	0.45	0.96	0.62	2.04	0.36	2.64	0.27	1.77	0.41	1.59	0.45	1.83	0.40	2.46	0.29	1.02	0.60
	r1 15
	r2 1
ethnicity (Wilcox test)	hispanic or latino 17	−0.09	0.11	−0.01	0.37	−0.11	0.24	−0.09	0.25	−0.09	0.37	−0.04	0.41	−0.13	0.28	−0.10	0.49	−0.05	0.48
	not hispanic or latino 310