Research Article
Combined Activation of Guanylate Cyclase and Cyclic AMP in Lung Fibroblasts as a Novel Therapeutic Concept for Lung Fibrosis
Figure 2
Concentration dependent antiproliferative action of sGC and cAMP activators on TGF-β1 induced fibroblast proliferation. (a) Concentration dependent antiproliferative effect of BAY 41-2272 over 3 days; (b) Concentration dependent anti-proliferative effect of forskolin. (c) Supportive effect of forskolin (10−10 – 10−6 M) on BAY 41-2272 (10−9 M) inhibition of fibroblast proliferation. (d) Supportive effect of BAY 41-2272 (10−12 – 10−8 M) on forskolin (10−9 M) inhibited proliferation. Bars represent mean ±SEM of triplicate experiments. indicates statistically significant difference (P<0.05) for comparison of TGF-β1 stimulation compared to drug effects.
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