Effect of Cilostazol on the Pharmacokinetics of Simvastatin in Healthy Subjects
Table 2
Pharmacokinetic parameters of simvastatin and its active metabolite, simvastatin acid, after a single oral administration of simvastatin 40 mg alone and in combination with multiple doses of cilostazol 100 mg in 17 healthy subjects.
Pharmacokinetic parameter
Simvastatin
Cilostazol + Simvastatin
Geometric least squares mean ratio
Point estimate
90% CI
Simvastatin
(μg/L)
5.84 (69.7)
10.27 (62.0)
1.7581
1.4167, 2.1819
(h·μg/L)
19.97 (78.8)
34.06 (67.2)
1.7059
1.4456, 2.0131
(h·μg/L)
23.15 (76.1)
38.02 (64.1)
1.6423
1.3812, 1.9527
(h)
1.5 (0.5, 4.0)
1.5 (0.5, 4.0)
-
-
(h)
3.73 (80.4)
3.74 (85.4)
-
-
Simvastatin acid
(μg/L)
2.48 (63.4)
3.92 (58.6)
1.5840
1.3025, 1.9263
(h·μg/L)
17.81 (70.5)
25.62 (62.6)
1.4389
1.2127, 1.7072
(h·μg/L)
23.08 (80.4)
30.27 (60.0)
1.3114
1.0363, 1.6596
(h)
4.0 (1.5, 6.0)
4.0 (2.0, 6.0)
-
-
(h)
5.97 (101.3)
5.39 (57.3)
-
-
Data are presented as geometric least squares mean (coefficient of variation), except which is presented as median (min, max).
