Research Article
Methylation Changes of Primary Tumors, Monolayer, and Spheroid Tissue Culture Environments in Malignant Melanoma and Breast Carcinoma
Table 6
Methylation rates of patients with malignant melanoma (2D: two-dimensional tissue culture, 3D: three-dimensional tissue culture, T: primary tumor tissue, and mg: malignant melanoma).
| Specimens | Methylation Rates () in |
| | 2 Dimensional Cell Culture () | 3 Dimensional Cell Culture () | Primer Tumor Tissue () |
| Specimen 1 |
| PAX5 | 52 | 51 | 50 |
| TMPRSS2 | 0 | 0 | 37 |
| SBDS | 0 | 0 | 0 |
| Specimen 2 | | | |
| PAX5 | 35 | 35 | 31 |
| TMPRSS2 | 0 | 0 | 0 |
| SBDS | 0 | 0 | 0 |
| Specimen 3 | | | |
| PAX5 | 22 | 24 | 42 |
| TMPRSS2 | 45 | 46 | 50 |
| SBDS | 0 | 0 | 38 |
| Specimen 4 | | | |
| PAX5 | 68 | 65 | 55 |
| TMPRSS2 | 47 | 45 | 39 |
| SBDS | 0 | 0 | 0 |
| Specimen 5 | | | |
| PAX5 | 50 | 48 | 42 |
| TMPRSS2 | 45 | 42 | 41 |
| SBDS | 0 | 0 | 0 |
| Specimen 6 | | | |
| PAX5 | 50 | 52 | 50 |
| TMPRSS2 | 51 | 52 | 48 |
| SBDS | 0 | 0 | 0 |
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