Research Article
Administration of Repetitive Transcranial Magnetic Stimulation Attenuates Aβ1-42-Induced Alzheimer’s Disease in Mice by Activating β-Catenin Signaling
Figure 2
Effect of rTMS on apoptosis and viability of neurons in hippocampus regions of AD mice. AD symptoms were induced with intracranial injection of 3 μl (1 μg/μl) and then treated with rTMS of 1 Hz or 10 Hz. Neuron apoptosis was detected with TUNEL staining and western blotting detection of cleaved caspase-3, Bax, and Bcl-2. Neuron viability was detected with immunochemical detection of doublecortin. (a) Representative images of TUNEL staining. (b) Quantitative analysis results and representative of western blotting detection. (c) Representative images of immunochemical detection of doublecortin. “” represents statistically significant different from Sham group, P < 0.05. “#” represents statistically significant different from AD group, P < 0.05. Scale bar, 200 μm. Each assay was represented by six replicates.
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