miR-451 Silencing Inhibited Doxorubicin Exposure-Induced Cardiotoxicity in Mice

Figure 4

miR-451 inhibition attenuated oxidative stress and apoptosis in mice. (a) The level of 4-HNE in the hearts (n=6). (b) The level of GSH/GSSG in the hearts (n=6). (c) The level of cardiac MDA (n=6). (d) The activity of SOD in the hearts (n=6). (e) Cell apoptosis detected by TUNEL staining (n=5). (f) The activity of caspase3 in the hearts (n=6). P<0.05 compared with the group with saline. ^#P<0.05 compared with mice after Dox injection.

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