Long Noncoding RNA MALAT1 Acts as a Competing Endogenous RNA to Regulate TGF-β2 Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells by a MicroRNA-26a-Dependent Mechanism

Figure 4

MALAT1 negatively regulated the expression of miR-26a. (a) The luciferase reporter assays identified that MALAT1 contains a binding site for miR-26a in HLECs. P < 0.05 compared with miR-26a mimics control group. (b) The levels of miR-26a were detected by qRT-PCR. P < 0.05 compared with TGF-β2 group. (c) The levels of MALAT1 were detected by qRT-PCR. P < 0.05 compared with pcDNA3.1-control group. (d) The levels of miR-26a were detected by qRT-PCR. P < 0.05 compared with pcDNA3.1-control group or pcDNA3.1-MALAT1-mut group. (e) The levels of MALAT1 were detected by qRT-PCR. (f) The levels of MALAT1 were detected by qRT-PCR. P < 0.05 compared with miR-26a control group. All of data are presented as the mean± SE of six independent experiments.

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