Development and Validation of a Novel Model to Predict Liver Histopathology in Patients with Chronic Hepatitis B

Table 1

Baseline characteristics of the study population in training cohort and in validation cohort.

Variables	Training cohort (n=126)	Validation cohort (n=132)	P
Male, sex, n (%)	90 (71.43)	106 (80.30)	0.095
Age, years	26.00 (18.00-39.00)	33.50 (24.30-49.10)	<0.001
HBeAg+, n (%)	123 (97.62)	89 (67.4)	<0.001
HBV DNA, lg copies/mL	3.72 (2.62-4.48)	7.62 (5.83-8.18)	<0.001
ALB, g/L	41.40 (35.70-46.13)	45.00 (43.00-47.00)	<0.001
GLB, g/L	29.90 (25.04-35.04)	31.00 (28.00-34.00)	0.047
TBil, μmol/L	16.30 (9.07-29.83)	12.25 (9.73-16.10)	<0.001
ALT, IU/L	44.50 (20.00-261.10)	73.00 (45.00-125.75)	<0.001
AST, IU/L	37.00 (22.00-125.50)	41.00 (28.00-68.75)	0.281
GGT, IU/L	21.50 (11.00-102.60)	26.00 (15.50-52.00)	0.388
ALP, IU/L	70.50 (43.80-122.30)	77.00 (61.00-88.00)	0.066
PT, s	12.30 (11.20-13.56)	11.50 (10.90-12.10)	<0.001
WBC, 10^9/L	6.15 (4.27-8.63)	5.39 (4.30-6.37)	<0.001
GR, %	55.75 (41.78-68.12)	57.95 (50.25-65.10)	0.097
Lym, %	35.30 (23.97-48.70)	31.20 (26.58-39.43)	0.006
RBC, 10^12/L	4.76 (4.14-5.36)	4.89 (4.62-5.26)	0.041
Hgb, g/L	146.00 (123.40-163.00)	151.00 (140.00-159.00)	0.012
PLT, 10^9/L	210.00 (141.70-265.70)	176.50 (144.00-215.25)	<0.001
Necroinflammation stage, n (%)
G0/G1/G2/G3/G4	0 (0.0)/34 (27.0)/56 (44.4)/28 (22.2)/8 (6.3)	17 (12.9)/28 (21.2)/49 (37.1)/36 (27.3)/2 (1.5)	<0.001
Significant inflammation (G2–G4)	92 (73.02)	87 (65.9)	0.216
Fibrosis stage, n (%)
S0/S1/S2/S3/S4	6 (4.8)/39 (31.0)/40 (31.7)/30 (23.8)/11 (8.7)	27 (20.5)/29 (22.0)/45 (34.1)/17 (12.9)/14 (10.6)	0.001
Significant fibrosis (S2-S4)	81 (64.29)	76 (57.6)	0.270

HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; GLB, globulin; ALB, albumin; TBil, total bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, gamma-glutamyl transpeptidase; PT, prothrombin; WBC, white blood count; GR, granulocyte ratio; RBC, lymphocyte ratio, red blood count; Hgb, hemoglobin; PLT, platelet count. Continuous variables were expressed as the median (25th to 75th percentile).