Development and Validation of a Novel Model to Predict Liver Histopathology in Patients with Chronic Hepatitis B

Table 3

Comparison of ATPI model with APRI, FIB-4, GPR, and HBeAg (+) model.

Models	Training cohort	Validation cohort
ATPI
AUC (95%Cl)	0.83 (0.75-0.89)	0.88 (0.81-0.93)
Cut-off values	1.53	1.53
Sensitivity/specificity (%)	63.64/92.59	69.47/91.89
PPV/NPV (%)	89.57/71.80	89.55/75.06
APRI
AUC (95%Cl)	0.79 (0.71-0.86)	0.87 (0.81-0.93)
Cut-off values	21.15	21.15
Sensitivity/specificity (%)	54.62/100.00	74.74/86.49
PPV/NPV (%)	100/68.79	84.69/77.40
Fib-4
AUC (95%Cl)	0.70 (0.62-0.78)	0.78 (0.70-0.84)
Cut-off values	0.66	0.66
Sensitivity/specificity (%)	60.61/74.07	83.16/43.24
PPV/NPV (%)	70.04/65.28	59.43/71.97
GPR
AUC (95%Cl)	0.76 (0.67-0.83)	0.80 (0.72-0.80)
Cut-off values	10.57	10.57
Sensitivity/specificity (%)	59.60/88.89	75.61/65.71
PPV/NPV (%)	84.29/68.75	68.80/72.93
HBeAg (+) model
AUC (95%Cl)	0.79 (0.71-0.86)	0.81 (0.74-0.88)
Cut-off values	3.61	3.61
Sensitivity/specificity (%)	56.57/92.59	93.68/35.14
PPV/NPV (%)	88.42/68.07	59.09/84.76
Comparison of AUC (P value)
ATPI vs. APRI	0.15	0.93
ATPI vs. Fib-4	0.03	0.02
ATPI vs. GPR	0.10	0.24
ATPI vs.HBeAg(+) model	0.33	0.17
APRI vs. Fib-4	0.09	0.01
APRI vs. GPR	0.44	0.23
APRI vs. HBeAg(+) model	0.89	0.17
Fib-4 vs. GPR	0.37	0.44
Fib-4 vs. HBeAg(+) model	0.09	0.48
GPR vs. HBeAg(+) model	0.48	0.84