Research Article
Development and Validation of a Novel Model to Predict Liver Histopathology in Patients with Chronic Hepatitis B
Table 3
Comparison of ATPI model with APRI, FIB-4, GPR, and HBeAg (+) model.
| Models | Training cohort | Validation cohort |
| ATPI | | | AUC (95%Cl) | 0.83 (0.75-0.89) | 0.88 (0.81-0.93) | Cut-off values | 1.53 | 1.53 | Sensitivity/specificity (%) | 63.64/92.59 | 69.47/91.89 | PPV/NPV (%) | 89.57/71.80 | 89.55/75.06 | APRI | | | AUC (95%Cl) | 0.79 (0.71-0.86) | 0.87 (0.81-0.93) | Cut-off values | 21.15 | 21.15 | Sensitivity/specificity (%) | 54.62/100.00 | 74.74/86.49 | PPV/NPV (%) | 100/68.79 | 84.69/77.40 | Fib-4 | | | AUC (95%Cl) | 0.70 (0.62-0.78) | 0.78 (0.70-0.84) | Cut-off values | 0.66 | 0.66 | Sensitivity/specificity (%) | 60.61/74.07 | 83.16/43.24 | PPV/NPV (%) | 70.04/65.28 | 59.43/71.97 | GPR | | | AUC (95%Cl) | 0.76 (0.67-0.83) | 0.80 (0.72-0.80) | Cut-off values | 10.57 | 10.57 | Sensitivity/specificity (%) | 59.60/88.89 | 75.61/65.71 | PPV/NPV (%) | 84.29/68.75 | 68.80/72.93 | HBeAg (+) model | | | AUC (95%Cl) | 0.79 (0.71-0.86) | 0.81 (0.74-0.88) | Cut-off values | 3.61 | 3.61 | Sensitivity/specificity (%) | 56.57/92.59 | 93.68/35.14 | PPV/NPV (%) | 88.42/68.07 | 59.09/84.76 | Comparison of AUC (P value) | | | ATPI vs. APRI | 0.15 | 0.93 | ATPI vs. Fib-4 | 0.03 | 0.02 | ATPI vs. GPR | 0.10 | 0.24 | ATPI vs.HBeAg(+) model | 0.33 | 0.17 | APRI vs. Fib-4 | 0.09 | 0.01 | APRI vs. GPR | 0.44 | 0.23 | APRI vs. HBeAg(+) model | 0.89 | 0.17 | Fib-4 vs. GPR | 0.37 | 0.44 | Fib-4 vs. HBeAg(+) model | 0.09 | 0.48 | GPR vs. HBeAg(+) model | 0.48 | 0.84 |
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