Can Inflammatory and Nutritional Serum Markers Predict Chemotherapy Outcomes and Survival in Advanced Stage Nonsmall Cell Lung Cancer Patients?

Table 2

Association between nutritional and inflammation parameters of the seven patients with advanced NSCLC.

Parameters	Prechemotherapy	2-month	4-month
Albumin
mean ± SD	4.07 ± 0.2	4.02 ± 0.2	4.04 ± 0.2	p =0.857
median (min/max)	4.0 (3.8/4.4)	4.0 (3.7/4.5)	3.9 (3.7/4.5)
Prealbumin
mean ± SD	19.0 ± 3.8	28.4 ± 7.8	21.1 ± 5.9	p = 0.007
median (min/max)	19.0 (14/25)	27.0 (18/40)	23 (11/29)
CRP
mean ± SD	37.3 ± 22.3	15.4 ± 13.6	35.8 ± 3.9	p = 0.368
median (min/max)	31 (18.9/79.9)	12.3 (1.8/36.1)	29.5 (3.8/83.5)
25-Cholecalciferol
mean ± SD	18.1 ± 4.9	18.7 ± 6.8	17.5 ± 5.3	p = 0.651
median (min/max)	17.6 (10.3/24.3)	19.6 (10/31.5)	17.3 (8.7/24.6)
Zinc
mean ± SD	56.8 ± 14.2	70.2 ± 10.9	63.6 ± 12.9	p = 0.102
median (min/max)	64.7 (39.9/72.3)	68.3 (59.6/89.7)	59.8 (47/80.3)
IL-6
mean ± SD	16.7 ± 12.0		4.7 ± 5.0	p = 1000
median (min/max)	13.3 (5.4/40.1)		16.4 (5.6/38.7)
IL-1β
mean ± SD	14.6 ± 15.5		16.7 ± 11.9	p = 0.018
median (min/max)	14.2 (0.7/46.7		0.7 (0.6/11.8)
TNF-α
mean± SD	53.5 ± 38.1		20.9 ± 11.2	p = 0.028
median (min/max)	46.7 (14.1/120)		17.1 (5.6/38.4)
LPL
mean ± SD	20.3 ± 12.5		15.4 ± 8.2	p = 0.018
median (min/max)	16.7 (7.5/44.5)		12.3 (6.3/30)
GPS n (%)	One abnormal (CRP >10 mg/L) score 1		7 (100 %)

n: number, CRP: C-reactive protein, IL6: interleukin 6, IL1-β: interleukin 1β, TNF-α: tumor necrosis factor alpha, LPL: lipoprotein lipase, values were based on Wilcoxon test, and Friedman test.