Review Article

A Glance at the Nuclear Envelope Spectrin Repeat Protein 3

Figure 1

The structure of nesprin-3. Nesprin-3 consists of a KASH domain and a series of SRs. Different from nesprin-1/2, nesprin-3 is lack of ABD. Nesprin-3 encodes two isoforms, nesprin-3α and nesprin-3β. The main structural difference is that nesprin-3α contains 8 SRs, while nesprin-3β only contains 7.