A Glance at the Nuclear Envelope Spectrin Repeat Protein 3

Figure 2

Nesprin-3 and its binding partners. Nesprin-3 is located on ONM. At nuclear membrane, it can interact with SUN proteins located on INM, meanwhile torsinA also bind with this combination to firm it. Inside the nuclear membrane, SUN proteins can interact with the nuclear lamin A, which connecting nucleoskeleton to LINC complex. Outside the nuclear membrane, nesprin-3 can link to cytoskeleton though indirectly. Plectin helps nesprin-3 connect to IF, while BPAG1 and MACF attach nesprin-3 to microtubes. Moreover, nesprin-3 can interact with other nesprins, like nesprin-1 and nesprin-2.