Research Article

Development of a Predictive Model of Difficult Hemostasis following Endobronchial Biopsy in Lung Cancer Patients

Table 1

Baseline characteristics and blood tests of the study participants.

VariablesDifficult hemostasisP value
No (n = 546)Yes (n = 74)

Gender, n (%)0.038
 Female124 (22.71)9 (12.16)
 Man422 (77.29)65 (87.84)
Age (years)65 (59-70)65 (59-70)0.757
Smoking, n (%)0.003
 No214 (39.19)16 (21.62)
 Yes332 (60.81)58 (78.38)
SBP (mmHg)131 (119-145)128 (111-143)0.184
DBP (mmHg)78 (70-86)70 (70-88)0.326
Weight (kg)60 (53-66)60 (53-70)0.353
COPD, n (%)0.738
 No511 (93.59)70 (94.59)
 Yes35 (6.41)4 (5.41)
Diabetes, n (%)0.410
 No516 (94.51)72 (97.30)
 Yes30 (5.49)2 (2.70)
CHD, n (%)0.722
 No529 (96.89)71 (95.95)
 Yes17 (3.11)3 (4.05)
Pulmonary infection, n (%)<0.001
 No340 (62.27)28 (37.84)
 Yes206 (37.73)46 (62.16)
Cancer stage, n (%)0.824
 Early295 (54.03)41 (55.41)
 Advanced251 (45.97)33 (44.59)
Histological types, n (%)<0.001
 Adenocarcinoma161 (29.49)5 (6.76)
 Squamous cell carcinoma254 (46.52)59 (79.73)
 SCLC101 (18.50)8 (10.81)
 Others30 (5.49)2 (2.70)
Lesion location, n (%)<0.001
 Left main bronchus29 (5.31)8 (10.81)
 Left upper lobar bronchi129 (23.63)13 (17.57)
 Left lower lobar bronchi98 (17.95)10 (13.51)
 Right main bronchus16 (2.93)8 (10.81)
 Right upper lobar bronchi137 (25.09)14 (18.92)
 Right middle bronchus21 (3.85)8 (10.81)
 Right middle lobar bronchi27 (4.95)2 (2.70)
 Right lower lobar bronchi84 (15.38)7 (9.46)
 The trachea5 (0.92)4 (5.41)
Hospitalization, (days)11 (7-15)10 (7-14)0.360
WBC (×109/L)6.80 (5.45-8.50)6.89 (5.43-8.88)0.914
Neutrophil (%)69.2 (61.8-75.6)72.6 (65.8-80.9)0.004
Neutrophils (×109/L)4.54 (3.50-6.35)5.10 (3.82-6.70)0.787
Hemoglobin (g/dl)128 (116-140)126 (112-137)0.256
Platelets (×109/L)222 (173-280)245 (171-317)0.086
CRP (mg/L)5.9 (1.1-31.8)18.66 (3.8-44.5)<0.001
PT (s)13.0 (12.1-13.6)13.3 (12.2-13.9)0.663
APTT (s)34.8 (31.5-38.2)36.2 (33.0-41.2)0.034
ALT (IU/L)17.0 (12.0-26.0)15.1 (12.0-21.4)0.184
AST (IU/L)23.0 (19.0-29.0)23.0 (18.0-27.1)0.233
Homocysteine (μmol/L)13.3 (10.7-16.6)12.7 (10.1-15.7)0.627
Triglyceride (mmol/L)1.08 (0.79-1.46)0.96 (0.71-1.15)0.006
TC (mmol/L)4.10 (3.46-4.77)4.06 (3.53-4.77)0.720
HDL-C (mmol/L)1.14 (0.94-1.37)1.07 (0.92-1.22)0.072
LDL-C (mmol/L)2.75 (2.26-3.30)2.86 (2.42-3.40)0.074
Apolipoprotein-B (g/L)0.96 (0.77-1.18)0.95 (0.80-1.15)0.425
Apolipoprotein-E (mg/dL)3.60 (2.90-4.80)2.95 (2.40-3.98)0.006

SBP, systolic blood pressure; DBP, diastolic blood pressure; COPD, chronic obstructive pulmonary disease; CHD, coronary heart disease; SCLC, small-cell lung carcinoma; WBC, white blood cell; CRP, C-reactive protein; PT, prothrombin time; APTT, activated partial thromboplastin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TC, total cholesterol; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol.