Correlations of Expression Levels of a Panel of Genes (IRF5, STAT4, TNFSF4, MECP2, and TLR7) and Cytokine Levels (IL-2, IL-6, IL-10, IL-12, IFN-γ, and TNF-α) with Systemic Lupus Erythematosus Outcomes in Jordanian Patients

Table 5

Correlations between expression levels of the studied genes and cytokines levels. Correlation studies were performed using Spearman’s rank correlation coefficient after normalization with the housekeeping gene GAPDH in SLE patients.

Gene/Cytokine		IRF5	TLR7	MECP2 (α)	MECP2 (β)	STAT (α)	STAT (β)	TNFSF4
TNF-α	R	−0.272	−0.153	−0.079	0.048	−0.204	−0.058	−0.123
		0.054	0.285	0.581	0.736	0.151	0.685	0.391
IFN-γ	R	−0.061	−0.056	0.037	0.014	−0.235	−0.113	−0.072
		0.672	0.697	0.795	0.925	0.097	0.429	0.617
IL-2	R	0.034	0.040	−0.085	0.014	−0.075	0.084	−0.074
		0.815	0.781	0.552	0.925	0.601	0.556	0.607
IL-12	R	−0.239	−0.365	−0.281	0.018	−0.331	−0.231	−0.394
		0.091	0.008	0.046	0.902	0.018	0.103	0.004
IL-6	R	0.002	−0.085	−0.210	0.136	0.080	−0.028	0.052
		0.988	0.555	0.140	0.341	0.575	0.846	0.717
IL-10	R	0.146	0.112	0.133	0.115	0.109	0.127	0.088
		0.308	0.435	0.352	0.423	0.446	0.376	0.538

Correlation is significant at the 0.05 level (2-tailed). Correlation is significant at the 0.01 level (2-tailed).