Correlations of Expression Levels of a Panel of Genes (IRF5, STAT4, TNFSF4, MECP2, and TLR7) and Cytokine Levels (IL-2, IL-6, IL-10, IL-12, IFN-γ, and TNF-α) with Systemic Lupus Erythematosus Outcomes in Jordanian Patients
Table 6
Relation between clinical manifestations and organ damage domains of SLE patients and expression levels of SLE genes and levels of cytokines.
Gene
Clinical manifestation
N
Organ damage
N
Cytokine
Clinical manifestation
N
Organ damage
N
IRF5
Malar rash
23
0.023
—
—
—
TNF-α
Nephropathy
22
0.026
Renal
16
0.013
Hypothyroidism
8
0.003
TLR7
Hypothyroidism
8
0.010
—
—
—
IL-6
Arthritis
13
0.013
Cardiovascular
7
0.041
Arthralgia
24
0.025
MECP2 (α)
Hypothyroidism
8
0.023
Renal
16
0.038
—
—
—
—
—
—
STAT4 (α)
Alopecia
11
0.048
Cardiovascular
7
0.007
IL-10
Hypothyroidism
8
0.004
—
—
—
Malar rash
23
0.039
Hypothyroidism
8
0.015
Ulceration of fingers
7
0.003
STAT4 (β)
Hypothyroidism
8
0.015
—
Ulceration of fingers
7
0.003
TNFSF4
Hypothyroidism
8
0.010
Musculoskeletal
6
0.043
Cardiovascular
7
0.011
Pulmonary
6
0.037
value < 0.05 is considered significant using the Mann–Whitney test. N is the number of patients showing the clinical manifestation or the organ damage.
