A Noninvasive Prediction Nomogram for Lymph Node Metastasis of Hepatocellular Carcinoma Based on Serum Long Noncoding RNAs

Table 3

Univariate and multivariate analyses of factors associated with lymph node metastasis of hepatocellular carcinoma among the training cohort.

Clinicopathological factors	Univariate			Multivariate (Adjusted)
	Hazard ratio	95% CI	P	Hazard ratio	95% CI	P
Age
≤ 51	1.0		0.286	-	-	-
> 51	0.6	0.3~1.5		-	-
Gender
male	1.0		0.187	-	-	-
female	3.9	0.5~28.9		-	-
HBsAg
negative	1.0		0.248	-	-	-
positive	0.5	0.1~1.7		-	-
HCV-Ab
negative	1.0		0.997	-	-	-
positive	0.0	0.0~Inf		-	-
AFP, ng/mL
≤ 20	1.0		0.539	-	-	-
> 20	0.7	0.3~1.9		-	-
Tumor differentiation
I-II	1.0		0.611	-	-	-
III-IV	1.3	0.5~3.3		-	-
Child-Pugh score
A	1.0		0.998	-	-	-
B	0.0	0.0~Inf		-	-
Intrahepatic metastasis
no	1.0		0.365	-	-	-
yes	1.5	0.6~3.8		-	-
Tumor size, cm
≤ 5	1.0		0.509	-	-	-
> 5	1.3	0.6~3.2		-	-
Vascular invasion
no	1.0		0.010	1.0		0.055
yes	3.2	1.3~7.6		2.5	1.0~6.5
BCLC stage
0-A	1.0		0.023	1.0		0.007
B-C	2.9	1.2~7.3		4.2	1.5~12.0
ALT, U/L
≤ 40	1.0		0.456	-	-	-
> 40	0.7	0.3~1.7		-	-
γ-GT, U/L
≤ 50	1.0		0.878	-	-	-
> 50	0.9	0.3~2.5		-	-
Liver cirrhosis
no	1.0		0.756	-	-	-
yes	1.3	0.3~5.4		-	-
Tumor number
single	1.0		0.585	-	-	-
multiple	0.8	0.3~2.1		-	-
Distant metastasis
no	1.0		0.752	-	-	-
yes	0.9	0.3~2.2		-	-
ENST00000418803
low expression	1.0		< 0.001	1.0		< 0.001
high expression	0.2	0.1~0.5		0.2	0.1~0.5
Lnc-EPS15L1-2:1
low expression	1.0		< 0.001	1.0		0.001
high expression	9	2.6~30.7		8.7	2.5~30.6
Lnc-ZNF35-4:1
low expression	1.0		0.001	1.0		0.025
high expression	0.2	0.1~0.5		0.3	0.1~0.9

HBsAg: hepatitis B surface antigen; HCV-Ab: hepatitis C virus antibody; AFP: a-fetoprotein; ALT: alanine aminotransferase; γ-GT: γ-glutamyl transferase; BCLC stage: Barcelona Clinic Liver Cancer stage; CI, confidence interval; : significance values.