Research Article
A Noninvasive Prediction Nomogram for Lymph Node Metastasis of Hepatocellular Carcinoma Based on Serum Long Noncoding RNAs
Table 3
Univariate and multivariate analyses of factors associated with lymph node metastasis of hepatocellular carcinoma among the training cohort.
| Clinicopathological factors | Univariate | Multivariate (Adjusted) | Hazard ratio | 95% CI | P | Hazard ratio | 95% CI | P |
| Age | | | | | | | ≤ 51 | 1.0 | | 0.286 | - | - | - | > 51 | 0.6 | 0.3~1.5 | - | - | Gender | | | | | | | male | 1.0 | | 0.187 | - | - | - | female | 3.9 | 0.5~28.9 | - | - | HBsAg | | | | | | | negative | 1.0 | | 0.248 | - | - | - | positive | 0.5 | 0.1~1.7 | - | - | HCV-Ab | | | | | | | negative | 1.0 | | 0.997 | - | - | - | positive | 0.0 | 0.0~Inf | - | - | AFP, ng/mL | | | | | | | ≤ 20 | 1.0 | | 0.539 | - | - | - | > 20 | 0.7 | 0.3~1.9 | - | - | Tumor differentiation | | | | | | | I-II | 1.0 | | 0.611 | - | - | - | III-IV | 1.3 | 0.5~3.3 | - | - | Child-Pugh score | | | | | | | A | 1.0 | | 0.998 | - | - | - | B | 0.0 | 0.0~Inf | - | - | Intrahepatic metastasis | | | | | | | no | 1.0 | | 0.365 | - | - | - | yes | 1.5 | 0.6~3.8 | - | - | Tumor size, cm | | | | | | | ≤ 5 | 1.0 | | 0.509 | - | - | - | > 5 | 1.3 | 0.6~3.2 | - | - | Vascular invasion | | | | | | | no | 1.0 | | 0.010 | 1.0 | | 0.055 | yes | 3.2 | 1.3~7.6 | 2.5 | 1.0~6.5 | BCLC stage | | | | | | | 0-A | 1.0 | | 0.023 | 1.0 | | 0.007 | B-C | 2.9 | 1.2~7.3 | 4.2 | 1.5~12.0 | ALT, U/L | | | | | | | ≤ 40 | 1.0 | | 0.456 | - | - | - | > 40 | 0.7 | 0.3~1.7 | - | - | γ-GT, U/L | | | | | | | ≤ 50 | 1.0 | | 0.878 | - | - | - | > 50 | 0.9 | 0.3~2.5 | - | - | Liver cirrhosis | | | | | | | no | 1.0 | | 0.756 | - | - | - | yes | 1.3 | 0.3~5.4 | - | - | Tumor number | | | | | | | single | 1.0 | | 0.585 | - | - | - | multiple | 0.8 | 0.3~2.1 | - | - | Distant metastasis | | | | | | | no | 1.0 | | 0.752 | - | - | - | yes | 0.9 | 0.3~2.2 | - | - | ENST00000418803 | | | | | | | low expression | 1.0 | | < 0.001 | 1.0 | | < 0.001 | high expression | 0.2 | 0.1~0.5 | 0.2 | 0.1~0.5 | Lnc-EPS15L1-2:1 | | | | | | | low expression | 1.0 | | < 0.001 | 1.0 | | 0.001 | high expression | 9 | 2.6~30.7 | 8.7 | 2.5~30.6 | Lnc-ZNF35-4:1 | | | | | | | low expression | 1.0 | | 0.001 | 1.0 | | 0.025 | high expression | 0.2 | 0.1~0.5 | 0.3 | 0.1~0.9 |
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HBsAg: hepatitis B surface antigen; HCV-Ab: hepatitis C virus antibody; AFP: a-fetoprotein; ALT: alanine aminotransferase; γ-GT: γ-glutamyl transferase; BCLC stage: Barcelona Clinic Liver Cancer stage; CI, confidence interval; : significance values. |