AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway
Elevated angiotensin II and descended angiotensin-(1-7) in heatstroke patients with liver dysfunction. Angiotensin II (Ang II) content (a) and angiotensin-(1-7) (Ang-(1-7)) content (b) in the serum of healthy controls (control), heatstroke patients without liver dysfunction (non-HD) and heatstroke patients with liver dysfunction (HD). The assays were performed in triplicate. P<0.05 compared with the control group and #P <0.05 compared with the non-HD group. (c) The receiver operating characteristic curves of Ang II, Ang-(1-7) and Ang II/Ang-(1-7) regarding the occurrence of liver dysfunction within one week after heatstroke. The AUC of three curves were significantly larger than 0.5 (P<0.001).
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