AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway

Figure 4

The effect of AVE 0991 on the production of reactive oxygen species induced by heat stress and Ang II. (a) The content of hydrogen peroxide and reduced glutathione in the liver tissue and cultured BRL-3A cells. Ang II and/or AVE 0991 were added to the supernatant for an additional 9 h after heat stress. (b) Reactive oxygen species were analysed by flow cytometry. The quantified percentages are shown in the graph (right). P<0.05 compared with the sham or control groups. #P<0.05 compared with the heat group. &P<0.05 compared with the heat+Ang II group. The data are presented as the mean ± SD. All of the assays were performed in triplicate.

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