Prediction and Structural Comparison of Deleterious Coding Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Human LEP Gene Associated with Obesity
Table 1
NsSNPs predicted as deleterious by SIFT and POLYPHEN.
SNP
MAF
AA Position
SIFT
Score
POLYPHEN
Score
rs866158426
NA
S46L
Deleterious
0.01
Probably_damaging
0.96
rs200575914
0.00000 (1/245916. GnomAD)
G59S
Deleterious
0
Probably_damaging
1
rs886061972
NA
D61N
Deleterious
0
Probably_damaging
0.96
rs724159998
0.00001 (1/121404. ExAC)
D100N
Deleterious
0
Probably_damaging
0.99
rs28954113
0.005 (27/5008. 1000G)
N103K
Deleterious
0
Probably_damaging
0.99
rs1051206328
NA
C117S
Deleterious
0
Probably_damaging
0.99
rs771956117
0.00001 (1/115652. ExAC)
L161R
Deleterious
0
Probably_damaging
1
rs1332916395
0.00001 (3/246190. GnomAD)
D76V
Deleterious
0
Probably_damaging
0.99
rs199838573
0.00000 (1/246242. GnomAD)
S88C
Deleterious
0
Probably_damaging
0.68
rs1206379074
0.00001 (1/125568. TOPMED)
P90R
Deleterious
0.02
Probably_damaging
0.60
rs1226851396
0.00001 (1/125568. TOPMED)
I95N
Deleterious
0.01
Probably_damaging
0.65
rs104894023
NA
R105W
Deleterious
0
Probably_damaging
0.99
GnomAD: The genome aggregation database. ExAC: The exome aggregation consortium. 1000G: 1000 genomes. TOPMED: The trans-omics for precision medicine. NA: Not available.
