Insights on the Multifunctional Activities of Magnolol

Table 2

The inhibitory effects of magnolol on different targets.

Substrate	Enzyme (target) source	IC50 (μM)	Ki (μM)	EC50 (μM)	Ref.
NF	CYP1A	1.62	1.09-12.0	-	[20]
SPZ	CYP2C	0.56	10.0-15.2	-
KCZ	CYP3A	35	93.7-183	-
meropenem	NDM-1	6.47 (μg/mL)	-	-	[60]
-	Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans	100	-	-	[61]
CP55,940	CB2	-	1.44	3.28	[25]
pNP-α-G	α-Glucosidase	2.0	-	-	[62]
4-hydroxy tolbutamide	CYP2C	41.48	-	-	[21]
dextrorphan	CYP2D6	65.42
6-hydroxy chlorzoxazone	CYP2E1	67.93
6-hydroxy testosterone	CYP3A4	52.36
hydroxybupropion	CYP2B6	28.69
p-NPP	PTP1B	24.6	-	-	[63]
-	PPARγ (agonist)	-	2.04	1.6	[64]
β-Estradiol	UGT1A1	36.8	-	-	[28]
β-Estradiol	Hela1A1	22.6	-	-
SN-38	UGT1A1	13.2	-	-
SN-38	Hela1A1	16.4	-	-
4-Mu	UGT1A7	-	0.487	-	[29]
4-Mu	UGT1A9	-	0.048	-