Clinical Features and Cytokine Profile in Myositis Patients with Anti-EJ Autoantibodies Detected by a Novel Immunoprecipitation Assay

Figure 4

Quantification of 27 cytokines and chemokines in sera of 4 anti-EJ positive patients and 7 normal controls using bead-based multiplex assays. (a) The levels of seven cytokines showed significant difference in anti-EJ positive patients, among which IP-10, IL-6, MCP-1, and VEGF were significantly elevated in anti-EJ positive patients compared with NC (P < 0.05, P < 0.01, ^&P < 0.001, vs. NC group). (b) The levels of IP-10, IL-6, MCP-1, and VEGF were gradually decreased in longitudinal sera from two patients and reached the levels of health control at 5 months after treatment, whereas eotaxin level was increased obviously after treatment.

(a)

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