2 Hz EA Reduces Heroin Withdrawal-Induced Hyperalgesia and Heroin Relapse by Downregulating P2X3 Receptors in DRG Neurons

Figure 1

Experimental timeline and diagram of the heroin self-administration (SA) and pain behavioural tests (thermal and mechanical nociceptive responses). Pain behavioural tests were performed on d −1 prior to heroin self-administration, on d 10 prior to extinction and 2 Hz EA treatment, and after d 24 cue-induced reinstatements.