Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases

Table 1

Studies demonstrating the quorum sensing (QS) signaling disruption by receptor inactivation. Abbreviations: 3-oxo-C12, N-3-oxododecanoyl-C12; AHL, N-acyl-homoserine lactones; AI, autoinducer; C4‐LHL, butenyl homoserine lactones; C6‐LHL, hexanoyl homoserine lactones; HSL, L-homoserine lactone; PHL, propionyl homoserine lactones.

Models	Strains	Anti-QS agents	Target	Effects	Ref
In-vitro	Pseudomonas aeruginosa	Flavonoids	Allosteric inhibition of AI-binding receptors, LasR and RhlR	Altered transcription of QS-controlled target promoters and suppresses virulence factor production	[53]
In-vitro	Pseudomonas aeruginosa PAO1	N-decanoyl-L-homoserine benzyl ester	Activating quorum sensing control repressor	Attenuated the activity of protease and elastase, swarming motility and biofilm formation	[54, 55]
In-vitro,; C. elegans, A549 cells,	Pseudomonas aeruginosa PA14	Meta-bromo-thiolactone	Inhibition of LasR and RhlR	Inhibited both the production of the virulence factor pyocyanin and biofilm formation	[57]
In-vitro	Pseudomonas aeruginosa	AHL ligands A4, 4-bromophenyl-PHL B7, 4-iodo PHL C10, and 3-nitro PHL C14	Binding to TraR, LasR, and; LuxR	Strongly inhibited virulence factor production	[58]
In-vitro,; Mice	Aeromonas hydrophila	C4- and C6-HSLs, 3-oxo-C12-HSL	Regulating the host immune receptor	Increased survivability of infected mice	[59]