Review Article
Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases
Table 2
Studies demonstrating the QS disruption by signals synthesis inhibition. Abbreviations: AI, autoinducer; enoyl-ACP, enoyl-acyl carrier protein; HSL, L-homoserine lactone; PHL, propionyl homoserine lactones.
| Models | Strains | Anti-QS agents | Target | Effects | Ref |
| In-vitro, Rats | Streptococcus pneumoniae D-39 | Sinefungin | Inhibition of AI-2 synthesis via downregulating luxS, pfs, and speE expression | Inhibited pneumococcal biofilm growth in vitro and middle ear colonization in vivo | [62] | In-vitro | Pseudomonas aeruginosa | Sinefungin, butyryl-SAM, and S-adenosylhomocysteine | Inhibiting acyl-HSL signals | Inhibited formation of a covalent acyl–enzyme | [61] | In-vitro | Escherichia coli | Methylthio-DADMe-immucillin-A | Downregulating 5′-methylthioadenosine, S-adenosyl-homocysteine nucleosidase hydrolyzes | Disrupted key bacterial pathways of methylation, polyamine synthesis, methionine salvage, and quorum sensing | [64] | Mouse | Plasmodium falciparum | Triclosan | Inhibiting enoyl-ACP reductase | Protected against blood stages of malaria, enhanced elastic strength | [66] |
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