Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases

Table 5

Studies demonstrating QS disruption by antibodies targeting.

Models	Strains	Anti-QS agents	Target	Effects	Ref
In-vitro and RAW 264.7 cells	Pseudomonas aeruginosa	Antibody RS2-1G9 generated against a 3-oxo-dodecanoyl homoserine lactone analog hapten	Targeting the bacterial N-3-oxo-dodecanoyl homoserine lactone molecules	Protect murine bone marrow-derived macrophages from the cytotoxic effects and also prevented the activation of the mitogen-activated protein kinase p38.	[100]
In-vitro	Pseudomonas aeruginosa	Antibody XYD-11G2	Hydrolyzing N-3-(oxododecanoyl)-L-homoserine lactone	Suppressed QS signaling.	[101]
In-vitro and mouse model	Staphylococcus aureus	Antibody AP4-24H11 elicited against a rationally designed hapten	Sequestration of the autoinducing peptide-4	Suppressed S. aureus pathogenicity in an abscess formation mouse model in vivo and provided complete protection against a lethal Staphylococcus aureus challenge.	[103]