Angiopoietin-1 Promotes the Integrity of Neovascularization in the Subcutaneous Matrigel of Type 1 Diabetic Rats

Figure 2

Electron micrographs of the newly formed microvessels in the Matrigel. Ultrastructural characterization of microvessels in the diabetes group of Matrigel; the microvessels have poorly organized basement membrane and swollen endothelial cells, as well as damaged endothelial tissue (Black arrow). Few pericytes are distributed around the endothelium, magnification ×20000. Ang-1 treated Matrigel showed complete endothelial structure with the typical tight junction (black arrows). Pericytes were observed to be in direct contact with endothelial cells. Multiple elongated pericytes are embedded within the intact basement membrane, magnification ×20000.