BioMed Research International / 2019 / Article / Tab 4

Research Article

Muscle Atrophy Marker Expression Differs between Rotary Cell Culture System and Animal Studies

Table 4

Fold change in gene expression of atrophy-indicating mRNAs from this in vitro study (ULA T25 12 days + RCCS 3 days) compared to referenced work in vivo, as measured by qPCR. ns = not significant, p<0.01, p<0.001.

In VitroIn VivoIn Vivo method

MuRF11.31.9, 1.6 [22]Casting 3 days, tenotomy 3 days
MAFbx1.32.7, 1.5 [22]Casting 3 days, tenotomy 3 days
Caspase 33.81.0, 3.3 [22]Casting 3 days, tenotomy 3 days
Ankrd11.13.9 [27]Hind limb unloading 6 days
Foxo31.41.6 [27]Hind limb unloading 6 days