Exosomes Modulate the Viral Replication and Host Immune Responses in HBV Infection

Table 1

HBV elements packaged within exosomes and their effects.

HBV element		Source	Effect	Ref.
HBV DNA	rcDNA	CHB patients serum	Transmit HBV infection	[23, 24]
	cccDNA
HBV RNA	HBx	HBx-expressing hepatoma cells; CHB patients serum	Transmit HBV infection	[23, 24, 28]
	HBs/p
HBV surface protein	HBsAg	CHB patients serum	Transmit HBV infection	[24]
HBV-encoded proteins	Large S	HepAD38 cell line with HBV replication	Transmit HBV infection	[25]
	Core protein
	P protein
	HBx protein	HBx-expressing hepatoma cells	Support viral spread and pathogenesis; export of intracellular A3G via exosome	[28, 29]
HBV-encoded miRNA	HBV-miR-3	HBV infected patients sera; HepG2.2.15 cells	Regulate HBV replication	[27]