Close Relationship between cIAP2 and Human ARDS Induced by Severe H7N9 Infection

Figure 7

Necroptosis was observed in SM-164 treated alveolar epithelium cells during LPS-induced ARDS. The mouse alveolar epithelium cell line MLE12 was exposed to SM-164 for 24h with or without LPS for 24h. RIPK3 and MLKL were downregulated along with the inhibition of cIAP2 by SM-164 during LPS-induced ARDS (a). The loss of viability is correlated with cell death as detected by LDH release in the cell supernatant ((b) and (c)). p<0.05.

(a)

(b)

(c)