Longitudinal Changes of PAI-1, MMP-2, and VEGF in Peritoneal Effluents and Their Associations with Peritoneal Small-Solute Transfer Rate in New Peritoneal Dialysis Patients

Table 2

Temporary trends of dialysate inflammatory markers (n = 70).

Variables		Mean	SD
Dialysate inflammatory markers
VEGF(pg/ml) (Baseline)		21.6	19.1-25.4
VEGF(pg/ml) (6 months)		22.2	19.7-27.5
	Paired test p-value	0.04
PAI-1(ng/ml) (Baseline)		0.6	0.3-1
PAI-1(ng/ml) (6 months)		1.1	0.8-1.6
	Paired test p-value	<0.001
MMP-2(ng/ml) (Baseline)		32.0	21.3-46.4
MMP-2(ng/ml) (6 months)		32.9	23.3-46.6
	Paired test p-value	0.73
Outcome
Follow-up interval (year)		2.24	1.96-2.46
4-hour D/P Creatinine (Baseline)		0.69	0.57-0.79
4-hour D/P Creatinine (2 years)		0.70	0.64-0.78
	Paired test p-value	0.02

Paired test p-value is estimated using paired t-test.
PD, peritoneal dialysis; ACEi, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blockade; VEGF, vascular endothelial growth factor; PAI-1, plasminogen activator inhibitor-1; MMP2, matrix metalloproteinases 2; D/P Cr, dialysate:plasma creatinine; PET, peritoneal equilibration test; Ccr, creatinine clearance rate; nPCR, normalized protein catabolic rate.